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Deca Durabolin

Nandrolone Decanoate ester, Nandrolone Base + Decanoate Ester

Formula (base): C18 H26 02
Formula (ester):C10 H20 02
Molecular Weight(base):274.4022
Molecular Weight (ester):172.2668
Melting Point (base): 122-124°C
Melting Point (ester):31 – 32 C
Manufacturer: various
Release Date (in USA): 1962
Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight)
Effective Dose (Women): 50-100mgs/week
Active life: 15 days
Detection Time: Up to 18 months
Anabolic/Androgenic ratio: 125:37

How to use Deca-Durabolin
Deca-Durabolin (”Deca”) is actually the brand name for Organon’s version of the compound Nandrolone Decanoate. This is a 19-Nor compound (some would say that it is the 19-nor compound), and as such, it shares basically the same characteristics with all of them. One thing that is unique about Deca above nearly all steroids is the mystique it has had for the last quarter of a century. Deca is included in many cycles at doses ranging from 100 rngs/week to 2,000 mgs per week.
Deca (and Nandrolone in general) doesn’t produce many estrogenic or androgenic side effects. This is because Deca has a very low rate of aromatization (conversion to estrogen via the aromatase enzyme). Its rate is roughly equal to 20% the rate of Testosterone.
In a study of postmenopausal women Deca improved collagen synthesis (1), and in another study, it increased bone mineral content (2). Both of these studies used VERY low doses, which were far too low to promote muscle growth. In my estimation, based on these 2 studies, an athlete attempting to use Deca only for these two effects (increasing bone mineral content and collagen synthesis) should be using 100mgs every week. That’s actually a higher dose than those two studies used successfully. Even at half of this dose, in HIV+ patients who have experienced significant wasting, a 100mg/E2W (every 2 weeks) injection of Deca resulted in a “significant increase in weight” (5). That low of a dose in not recommended for athletes, but it is evidence of Deca’s strong anabolic properties. Deca is a very nice anabolic, causing nice (albeit slow) gain in quality muscle. This could be due to its moderately strong binding to the Androgen Receptor, or its many positive non¬Androgen-Receptor mediated effects. One such effect is nitrogen retention, which is a major factor in muscle growth and lean mass gains. In one study, with low-doses (65 mg/week) and high-doses of Deca (200 mg/week), both low-doses and high-doses resulted in significant nitrogen retention (33-52 g nitrogen/14 days, representing gains of 0.5 to 0.9 kg lean tissue/week), and body weight increased by 4.9 +/- 1.2 kg, including 3.1 +/- 0.5 kg lean body mass, and treadmill exercise performance (cardiovascular fitness) also improved (7). The higher doses in this study produced more gains. Athletes and bodybuilders who have posted their results with Deca confirm this in many posts and threads, with their average recommendation being to take 400-600mgs/week for muscle gain.
Deca also has a very long active life. We can see from the chart below that a 100mg shot (represented by the circles) produced relatively active and stable plasma nandrolone levels almost until day 10, hence, once a week shots are all that’s necessary for stable levels of nandrolone decanoate (as a side note, the nandrolone phenylpropionate used in this study was active, and only experienced a severe drop off around day 5—shooting NPP every 4th day is the way to go). You’ll also note that higher blood plasma levels of Nandrolone are found with Gluteal injections as opposed to Deltoid injections (this is true for all oil-based steroids).
In another study of HIV+ men (6) we can see that Deca (200mgs on week 1, 400 on week 2 and 600mgs for weeks 3-12) caused no negative side effects in total or LDL cholesterol, triglycerides, or insulin sensitivity and there was a reduction of HDL cholesterol(8-10 points) in both groups. Also, in most studies with HIV+ subjects, Deca also improved immune function.
Deca is a very safe drug for long term use, will help with joint problems, could improve immune function, and is highly (!) anabolic and not very androgenic. That’s the good news (and there’s a lot of it)…now for the bad news. Judging from athletes and bodybuilders feedback Deca is known for producing quality weight gains, but it has to be used for 12 weeks at a minimum. This shouldn’t cause any problems, since it is a very mild drug in terms of side-effects. Many athletes and bodybuilders also complain of water-retention with this drug. Letrozole seems to be a preferred choice to combat this, and it’s my favorite for this use. This water retention would seem to make Deca more suitable for bulking rather than cutting; although, it can be successfully used for either.

Unwanted Effects of Deca-Durabolin
Now for the worst news: unfortunately, Deca is a progestin (as are all nandrolones), and it happens to stimulate the progesterone receptor 20% as well as progesterone itself (3). This opens the door for many possible unwanted side effects (water retention, acne, etc…). It must be noted that most of those are rare, though. This also may be the major reason why Deca is such a suppressive drug when it comes to your natural testosterone levels. A single measly 100mg injection of Deca caused a total (100%) reduction of natural testosterone levels, and it took roughly a month to return those testosterone levels to baseline! All from 100mgs of Deca!

Always use testosterone with your Deca! It is suggested 200mgs minimum to avoid impotence and sexual dysfunction. For an anabolic effect from that of Testosterone, we recommend at least double that, with an equal amount of Deca (minimum). Anti-progesteronic drug is also recommended taking an with Deca.
Deca is recommended for a bulking cycle with a dosage of up to 600mgs/week for an extended duration (12-16 weeks), or up to 400mgs/week in a cutting cycle (again, for 12-16 weeks), as long as something to combat water retention was present. Whatever purpose you decide to use Deca for, you still need to include Testosterone in your cycle and have some anti-progesteronic drugs on hand (see paragraph above), just in case.
Post Cycle Therapy (PCT), though beyond the scope of this profile, needs to be discussed. Due to the highly suppressive nature of Deca, I will speculate that testosterone in a deca-inclusive cycle must run for at least 2 additional weeks upon cessation of Deca. Baseline testosterone levels take roughly a month to return. Hence, a nice long estered testosterone should run for an additional 2 weeks. This is to prevent having a lag in time when the Deca is not producing an anabolic effect, yet is still suppressing your natural testosterone levels. I’d also suggest that a particularly aggressive PCT be run after your cycle; nolvadex, HCG, and perhaps clomid should all be utilized in an effort to restore your natural hormone levels as quickly and efficiently as possible.

Buying this product as a human-grade pharmaceutical from a dealer who stocks the Organon brand will be an expensive proposition. Buying veterinary grade will lower the cost. There are also many underground labs, which produce this drug and usually 10-20mls of a 200mg/ml concentration at reasonable prices.

1. Metabolism. 1990 Nov; 39(11):1167-9
2. Effects of nandrolone decanoate on bone mineral content R, Righi GA, Turchetti V, Vattimo A.).
3. . Cancer Res 1978 Nov; 38(11 Pt 2):4186-98
4. (Charts) from Minto et al
5. AIDS. 1996 Jun; 10(7):745-52
6. Sattler et al. Am J Physiol Endocrinol Metab 283: e1214-22
7. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 1; 20(2):137-46.