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Durabolin

Nandrolone with Phenylpropionate ester, NPP

Formula (base): C18 H26 02
Formula (ester): C9 H10 02
Molecular Weight(base):274.4022
Molecular Weight (ester): 150.174
Melting Point (base): 122-124°C
Melting Point (ester): 20°C
Manufacturer: Organon
Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight)
Effective Dose (Women): 50-100mgs/week
Active life: 5 days
Detection Time: Up to 12 months
Anabolic: Androgenic ratio: 37:125
Effective Dose (Men): 300-600mgs/week
Effective Dose (Women): 50-100mgs/week

Nandrolone is a modification of testosterone (carbon atom removed from the 19th position). With an Anabolic/Androgenic ratio: 37:125 it is highly anabolic (muscle building) and moderately androgenic (male characteristics). Due to nandrolone’s chemical structure, it only aromatizes (converts to estrogen) slightly, at about 20% the rate of testosterone when it interacts with the aromatase enzyme. Ergo, estrogenic effects are not a major concern with its use. Of note, however, is that nandrolone is a progestin with a binding affinity of 20% to the progesterone receptor (15) (PgR), so side effects are still possible, though rare. The development of breast tissue in males (gynecomastia) has been reported by some users. Besides being one of the most popular anabolic steroid used in bodybuilding cycles, nandrolone is also (medically) used to treat severe debility or disease states, and refractory anemias (1). It promotes tissue building processes, reverses catabolism (muscle destruction) and stimulates erythropoiesis (red blood cell production). This makes it a very useful drug to treat wasting disorders such as advanced H.I.V. (2) (16), and also, makes it highly sought after by bodybuilders and athletes.
Nandrolone is most commonly found with a cypionate, laurate, decanoate or plenylpropionate ester. Briefly explained, the ester determines how much of the given hormone is released over a period of time. Longer esters such as decanoate peak slowly and can keep stable blood plasma levels up to ten days. Shorter esters, such as the phenylpropionate, peak more rapidly but the half-live is shorter. Shorter esters usually release much more active hormones per mg than longer esters, and of course, allow the drug’s effects to leave your system more quickly. Surprisingly, NPP (Durabolin) and ND (Deca) release almost the same amount of active nandrolone per 100mgs: 69% and 65% respectively; this does not correlate exactly though because blood levels of nandrolone are much higher (about doubled) post NPP usage compared to the same 100mg dose of ND (see chart). NPP also has more distinct advantages over ND. One of the most common complaints about adding ND (Deca) to a cycle is the water retention that accompanies its use (3). Gains from NPP are reported to be “clean” with minimal water retention and fat gain. While ND is usually used in “bulking” cycles, NPP is used in “cutting” cycles, although either drug can be used in either regard. Being an oil based anabolic it is injected intramuscularly (into the muscle); many users inject it ED or EOD, however, NPP can be administered E4D without problems.
NPP and nandrolone in general have a number of benefits for athletes; they increase levels of serotonergic amines in the brain. These chemicals contribute to aggressive behavior. This could help athletes train harder and improve speed and power (4). Nandrolone also increases levels of IGF-1 in muscle tissues (5). This may be another reason why nandrolone is highly anabolic. NPP also benefits the athlete by increasing the number of androgen receptors (AR). One study showed that when nandrolone was given to rats at a dosage of 6mg/kg of bodyweight and was combined with muscle functional overload (muscle functional overload gives a similar effect to resistance training) it had a 1,300% (!) increase in AR protein concentrations (6). There is a direct link to muscle growth and AR levels. NPP also seems to be a promising fat loss agent. Men who were given the drug had reduced levels of subcutaneous (under skin), adipose (fat) tissue, and visceral (gut) however, fat loss was not as good (7). The fat loss effect seems though to be dose dependant. In one study, NPP at a daily dose of 1, 4, or 10mg per kg of bodyweight, the 10mg dose had the greatest effect on fat loss (8). NPP is used to treat anemia by stimulating red blood cell production (1). An increase in RBC count can improve endurance during exercise via better lactic acid clearing and oxygen delivery. The blood is also better enabled to carry nutrients to muscle tissue to aid in repair. Administration also increases the rate of muscle glycogen repletion after exercise, helping the athlete to dramatically recover after strenuous physical exercise (9). Athletes who require a high level of endurance in their chosen sport can benefit from the use of NPP (15). A favorite with bodybuilders who suffer with sore joints, NPP can also improve collagen synthesis (10), which may improve joint function and alleviate joint pains. Many athletes and bodybuilders swear by nandrolone’s ability to allow them to train in comfort.

Unwanted Effects
Many nandrolone lovers claim that it is one of the safest anabolic steroids, if not the safest. It does have side effects that can be bothersome to hypersensitive individuals such as acne, excitation, insomnia, nausea, diarrhea, and bladder irritability (1). More serious (and common) side effects include testicular atrophy (shrunken balls), impotence (Deca dick) and gynecomastia (bitch tits) (1). Nandrolone use has been shown to be safe and easy on the lipid profile, often improving HDL Cholesterol (16) Impotence can be offset by stacking the nandrolone with a higher testosterone. Nandrolone also causes the “shut down” (total stoppage) of endogenous (natural) testosterone production. Thus an exogenous (outside) source must be provided. The increased prolactin levels from the use of a progestenic steroid contribute to HPTA shut down and testicular atrophy, which can be treated with a combination HCG (a female hormone that acts like LH when introduced into the male body) and bromocriptine (a dopamine receptor agonist that, among other things, can lower prolactin levels) (1)(11).

Usage
NPP can be highly useful in either “bulking” or “cutting” cycles, and it would seem that diet and dosages are the determining factors of whether a cycle with this drug will be one or the other. Due to its highly anabolic nature, coupled with low androgenic properties, it can be incorporated into a mass cycle that is usually stacked with testosterone and a powerful oral like, possibly, oxymetholone (Anadrol) or methandrostenolone (Dianabol). NPP can thus be part of a classic bulking cycle. For a cutting cycle NPP is usually be combined with other short-estered injectable anabolic steroids (testosterone propionate and boldenone acetate come to mind as likely choices) and one of the DHT derived orals such as stanozolol (winstrol) or oxandrolone (Anavar). NPP is said to produce good mass and strength gains in both cutting and bulking cycle phases (3). When one is planning a cutting cycle one must take caution if combining the 19-nor-testosterone derivative trenbolone with nandrolone. Trenbolone Acetate, although a powerful drug for lean muscle gains, strength, and fat loss, is also a strong progestin with a binding affinity to the PgR of 60% (3x that of nandrolone). The elevated prolactin can worsen HPTA insult, often causing the user to spend more money on preventative measures. The combo may also result in a difficult PCT protocol to regain natural testosterone production. So far, few athletes have had any first- hand experience with NPP because it is limited to the few who know which UGLabs sells this particular form of nandrolone. This increases the popularity of “home brewing” since the powder comes out of China at very affordable prices. It is only a matter of time before NPP (or Durabolin) takes a special place in the arsenal of athletes and bodybuilders in their quest for more muscle.

References
1. Nursing2003 drug handbook.
2. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6): E1214-22.
3. Online forums.
4. Med Sci Sports Exerc. 2003 Jan; 35(1): 32-8.
5. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2): E483-90
6. J Appl. Physio1.94 1153-61 2003
7. Int J Obes Relat Metab Disord. 1995 Sep; 19(9): 614-24.
8. Ann Nutr Metab. 1991; 35(3): 141-7.
9. J Vet Med A Physiol Pathol Clin Med. 2001 Aug; 48(6): 343-52
10. Metabolism. 1990 Nov; 39(11): 1167-9.)
11. Pharmacol Biochem Behay. 1988 Mar; 29(3): 489-93.
12. Cancer Res. 2003 Oct 1; 63(19): 6523-31.)
13. Expert Opin Pharmacother. 2004 Dec; 5(12): 2549-58.
14. Cancer Res 1978 Nov; 38(11 Pt 2): 4186-98
15. Med Sci Sports Exerc. 1995 Oct;27(10):1385-9.
16. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-22. Epub 2002 Aug 27.

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