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Halotestin (Fluoxymesterone)

Date Released: 1957
Effective Dose: 10-40mgs/day
Active life: 6-8 hours
Detection Time: 2 months
Anabolic/Androgenic ratio: 1,900/850

Halotestin is legendary among powerlifters and strength athletes. The mere word conjures up images of little mint colored pills that turn Dr. Jeckyl instantly into Mr. Hyde.
Halotestin has an absurd Anabolic and Androgenic rating. This stuff is 19 times as anabolic as testosterone and 8.5 times as androgenic! We must admit, those numbers are a bit deceiving, and can be said that Halotestin will not put anywhere near as much muscle on you as testosterone. Let’s take a closer look at Halotestin, see what kind of realistic effects we can expect from it, and what kind of side-effects we’ll be dealing with.
Its use in athletics and powerlifting in general is far more pronounced than its use in bodybuilding. Here, it is basically a one-trick-wonder used in the final weeks before a contest to harden up an already lean physique and gives the user some added aggression during the final calorie depleted workouts before a contest. Halotestin has no estrogenic activity, and thus will not cause any kind of water retention or most of the bad effects associated with estrogen. It is, however, hepatoxic (liver toxic) and recommended keeping doses at or around 40mgs/day for a maximum of 4-6 weeks. If you are using it for its pronounced effect on aggression, you can simply use 10mgs prior to a workout. It is preferred by a lot of athletes 10mgs upon rising and 10mgs prior to a workout during the most intense weeks of a bulking or cutting cycle. This can be used with minimum HPTA inhibition.
It also has a volumizing effect on the physique, and for those who have a low a bodyfat percentage, this will immediately cause a more contest ready appearance. This is due, at least in part, to Halotestin’s ability to increase mean hematocrit with hemoglobin levels as well as red cell mass. Halotestin also appears to act through cells already committed to respond to erythropoietin. This is good news for athletes, of course. As you can see, Halotestin has quite a profound effect on red blood cell production. This action is clearly one of the most obvious mechanisms and its effects increase strength and energy levels. It also points to the possibility of using it for athletics and sports where a high VO2 max is needed for activities such as Rugby, Mixed Martial Arts, etc…
It also exerts its effects on strength and fat loss by regulating fatty acid oxidation in the liver and fast-twitch muscle mitochondria. Oddly, for a drug that exerts such a nice anabolic effect and promotes such good strength gains, it has a pretty low Androgen Receptor Binding affinity. In this respect, it can be compared to Winstrol (Stanozolol).
As far as strength and aggression goes, Halo is a great drug. It is especially useful on a cutting or strength cycle. Its use for mass and weight gain have been pretty disappointing for most users.
Fluoxymesterone administration is (unfortunately) accompanied by a reduction in thyroid binding globulin which causes associated decreases in T3, while the free T4 index remains totally unaltered, thus, implying that thyroid function was unchanged. Remember, many anabolic steroids (notably Trenbolone) lower your T3 levels. In addition, during fluoxymesterone administration there was a reduction in testosterone, gonadotrophins and LH response to LHRH. Basal TSH did not vary, but there was a reduction in the peak and integrated TSH response to TRH. PRL levels tend to remain unchanged during fluoxymesterone use. Halotestin is of course suppressive to your HPTA, but can be found that in some studies where measurements were made of serum FSH, LH, testosterone, up to 20mgs per day of Halotestin did not suppress them measurably. This could possibly indicate the use of up to 20mgs/day of Ha lotestin without being in any great danger of suppressing endogenous hormones.
Halotestin is a testosterone derived steroid, and has an 11-beta group attached to it to inhibit aromatization. Although it is particularly prone to being 5-alpha-reduced and may cause DHT related side effects such as acne and hair loss. It is metabolized primarily by 6 beta-hydroxylation, 4-ene-reduction, 3-keto-reduction, and 11- hydroxy-oxidation. We know this by the identification of 4 particular metabolites and the tentative identification of at least 3 other metabolites. Detection of Halotestin in urine is possible for at least 5 days after a single 10 mg oral dose to previously untreated adult males. This occurs by monitoring the presence of 2 metabolites, since the parent drug is not detectable more than 1 day after the dose . However, the moral-compass of the athletic world, the IOC, has developed a test for fluoxymesterone metabolites that will detect them for up to 2 months after cessation of use. This item is not in high demand in bodybuilding except for as a pre-contest drug and would more likely be found circulating in Athletic and Powerlifting circles where it is more commonly used in a cycle.