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Methyltrienolone

Methyltrienolone MT

[17beta-Hydroxy-17-methylestra-4,9,11-trien-3-one]
Formula: C19H2402 Molecular Weight: 284.38
Melting Point: 170C
Manufacturer: Negma (never released), Underground Labs
Effective dose: 500-750mcgs/day
Active Life: 4-6hours
Detection Time: Unknown (Probably up to 6 weeks)
Anabolic/Androgenic Ratio (Range, estimated):12,000-30,000/6,000-7,000

Methyltrienolone (MT) is a very potent, reasonably toxic, non-aromatizing steroid.
MT is potent since it binds so strongly to the AR (androgen receptor) that it is often used in studies on other androgens to measure how strongly they bind. In other words, this stuff binds onto the AR receptor so strongly that it is pretty much the benchmark for that quality. If you’ve read my profile on trenbolone acetate (TA), you’ll note that I said TA is the most potent injectable weapon in our arsenal with regards to ability to bind to the androgen receptor. That’s still true, because this particular compound is not in our arsenal, and it’s simply the oral version of TA (i.e. it is trenbolone which has undergone modification to become orally active, via the addition of a 17-alph-methyl group).
So why is it important that this stuff binds so tightly to the AR? Androgen receptors are found in both fat cells and muscle cells (8); they act on the AR in muscle cells to promote growth, and in the fat cells to affect fat burning (9)(6). The stronger the androgen binds to the AR, the higher the lipolytic (fat burning) effect on adipose (fat) tissue (9)(5). Unfortunately, that strong binding doesn’t also automatically mean that it will elicit the strongest possible anabolic response, nor that the weakest bind will elicit a weak anabolic response. Anadrol has the weakest bind to the AR possible (too low to be measured), and it produces a profound anabolic response, for example. Don’t be fooled by the anabolic/androgenic ratio of this (or any steroid) either. The anabolic/androgenic ratio of MT would suggest that it produces 5-times the anabolic and androgenic effect of testosterone (which has a score of 100 and 100 respectively). If one were able to get a bottle of this stuff, I believe it would be best used as part of a cutting cycle, stacked with some injectables (testosterone, etc…), but certainly no other orals. It’s just too toxic. Negma (the French company who brought Parabolan to the market, and then discontinued it) never pushed MT to gain approval as a commercially released item, since their original studies showed it to be highly toxic.
But, remember, AR’s are found in muscle tissue as well. When a muscle’s AR is stimulated, it can induce hypertrophy. When an adipose tissue’s AR is stimulated, through various related mechanisms, fat is lost. This is a gross oversimplification. All we need to know is that when you have a steroid that binds to the AR, it builds muscle and burns fat, and a steroid that binds very tightly to the AR will stimulate a lot of muscle synthesis and burn a lot of fat. A good example of this is Trenbolone. And since I mentioned Trenbolone, it’s worth further mentioning that MT is basically a 17aa (oral) version of (injectable) Trenbolone. AR binding and AR stimulation is not the only mechanism which stimulates anabolism, however. It’s important to note that dbol has a very low AR binding ability and A50 has an AR binding ability that is too low to even measure! Both are very potent oral steroids, though. So while it’s important, AR binding/stimulation is not the end all and be all of anabolism.

Usage
Methyltrienolone is, of course, a 19Nor compound (as is Trenbolone). It will effect your sexual drive and performance in a similar way to both Tren and nandrolone, meaning that temporary impotence and/or a lack of libido is highly possible (aka Tren-Dick or Deca Dick) (10). Also, it is a progestin, and still binds almost as well to the progesterone receptor (PgR) (3). As we know, progestins amplify estrogenic effects of aromatizing drugs. Although MT doesn’t aromatize, you will still need to worry about its ability to cause side-effects by amplifying the estrogenic issues caused by the other compounds you may be taking.

Unwanted Effects
How toxic is this stuff? Well, it was never commercially marketed for use in humans, and has been relegated to Steroid-Purgatory, to be used only in studies. It can be rated on around the same level as taking high(ish) doses of halotestin or methyltestosterone. It is recommended that people keep doses of this product very low, much lower than recommended doses typical of the other 2 compounds I just mentioned (i.e. 500-750mcgs/day…for not much longer than 3-4 weeks). People who were in the 2mg/day range developed highly elevated liver enzymes and jaundice (yellowing of the eyes and skin). They all recovered, and through trial and error, a 500-750mcg dose was found to be (relatively) safe, and (roughly) as effective as 150-225mgs of Trenbolone Acetate. For women, a possible side effect of MT is virilization (development of male sexual characteristics), which is profound with this stuff (11), so it is entirely off limits for women to use.
With this stuff, you may want to take milk thistle (320mgs/day), ALA (500mgs per meal) and try some Pygeum Africanum (Permixon, the liposterolic extract of Serenoa). This stuff will protect your prostate: in one study, it inhibited competitively the binding of methyltrienolone to the cytosolic receptor of the rat prostate. You’ll still need to get blood work done, avoid other orals (this includes drinking, or anything else which could tax your liver), and monitor your health closely. This isn’t a drug for novices, clearly, and is probably only useful for pre-contest bodybuilders.

References
1. Endocrinology. 1984 Jun;114(6):2100-6.Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.
2. Bonne C, Raynaud JP. Methyltrienolone, a specific ligand for cellular androgen receptors. Steroids 1975 Aug;26(2):227-32
3. Dube JY, Tremblay RR, Chapdelaine P. Binding of methyltrienolone to various androgen-dependent and androgen-responsive tissues in four animal species. Horm Res 1976;7(6):333-40
4. Tremblay RR, Dube JY, Ho-Kim MA, Lesage R. Determination of rat muscles androgen-receptor complexes with methyltrienolone. Steroids 1977 Feb;29(2):185-95
5. APMIS. 2000 Dec; 108(12):838-46.5. APMIS. 2000 Dec; 108(12):838-46.
6. (Xu X, et al. “The effects of androgens on the regulation of lipolysis in adipose precursor cells.” Endocrinology 1990 Feb;126(2):1229 ).
7. J Anim Sci. 1992 Nov;70(11):3381-90.
8. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52.
9. Biochim Biophys Acta. 1995 May 11;1244(l):117-20.
10. Baum MJ, Kingsbury PA, Erskine MS. Failure of the synthetic androgen 17 beta┬Čhydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R1881) to duplicate the activational effect of testosterone on mating in castrated male rats. J Endocrinol 1987 Apr;113(1):15-20
11. Biochem Pharmacol. 1984 Apr 15;33(8):1235-41.Changes in the activities of microsomal enzymes involved in hepatic steroid metabolism in the rat after administration of androgenic, estrogenic, progestational, anabolic and catatoxic steroids.

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