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Sustanon 250

(Testosterone plus Testosterone with Propionate, Phenylpropionate, Isocaproate, and Decanoate esters)

Manufacturer: Organon, Asia Dispensary, British Dragon, Eco Oils
Effective Dose (Men): 500-2000mg/ week
Effective Dose (Women): Not recommended
Active life: Up to 3 weeks
Detection Time: 3+ months
Anabolic/Androgenic ratio:100/100

This product was developed by Organon as an ideal HRT (Hormone Replacement Therapy) solution, and it was thought at the time that the different esters would be able to provide a constant release of Testosterone over several months time. Sustanon is a blend of different estered testosterones (4 of them): testosterone propionate – 30 mg, testosterone phenylpropionate – 60 mg, testosterone isocaproate – 60mg, and testosterone decanoate -100 mg.

This drug was highly sought after as a “superior” version of testosterone in the late 80’s and through the mid 90’s. No doubt this is partly due to the very nice write-up Dan Duchaine gave it in his newsletters. However, let’s keep in mind that this drug was designed for convenience, not athletics or bodybuilding. The advantage to this drug, according to the manufacturer, is that it can be injected once a month, and the different esters would provide different timed releases over that month, and the patient would therefore only need to visit the doctor once a month for his shot. For athletes or bodybuilders (who routinely use between half a gram and a gram of testosterone per week), this product is really no better than any other form of injectable testosterone.
Lately, it seems that this product has fallen out of favor with athletes, as many feel that the inclusion of the Propionate and phenylpropionate estered forms of testosterone in this blend would necessitate shooting every other day. This stems from the fact that testosterone propionate would be shot every other day at least, and testosterone phenylpropionate would generally be shot every third day.

Sustanon will do exactly what other forms of testosterone will do:
Testosterone will cause both muscle growth as well as fat loss. It sends a message to muscle cells to store more contractile protein (called actin and myosin), thus making your muscles grow. It also protects your muscles from catabolic (muscle wasting) glucocorticoid hormones (1). Thus it is often said that testosterone is not only anabolic, but it is strongly catabolic. Not only does it cause an increase in size of the muscle fibers (hyperfascia) but it also can change the appearance and the actual number of muscle fibers (Hyperplasia) (2). Testosterone has the ability to increase erythropoiesis (red blood cell production) in your kidneys (4), and a higher Red Blood Cell (RBC) count may improve endurance by producing more highly oxygenated blood. More RBCs can also improve recovery from strenuous physical activity. Aggression levels often rise dramatically with the use of any exogenous testosterone (3). Testosterone improves muscle contraction by increasing the number of motor neutrons in muscle (5) and improves neuromuscular transmission (6). It also promotes glycogen synthesis (7)

Since Sustanon is simply a form of (well actually 4 forms of) testosterone, we also know that administration of this compound will produce a dose respondent curve (10). A what? Yeah, basically, a “dose respondent curve” is the fancy way of saying “the more you take, the bigger you get.” This is true of Sustanon as well as for every form of testosterone, up to a point.
Unfortunately, Sustanon will also do all of the bad things that any form of testosterone is known for: It will convert to the female hormone estrogen (via a mechanism known as aromatization) by the (you guessed it) aromatize enzyme. Excessive estrogen can lead to unwanted side effects, such as acne, the growth of breast tissue (gynecomastia), fat gain and reduced fat breakdown, loss of sex drive, testicular shrinkage and water retention. Water retention can increase blood pressure weakening blood vessels over time. Unfortunately, this isn’t all it does: it can also interact with the 5 alpha-reductase enzyme. This interaction converts the testosterone to Dihydro-testosterone (DHT), a more androgenic form of the parent hormone. DHT has a high binding affinity to the tissues of the scalp resulting in hair loss in loss in users who suffer from male pattern baldness. DHT can affect the prostate as well, making it larger. This swelling can cause the gland to press against the bladder causing urinary problems. Drugs called 5alpha-reductase inhibitors can prevent these symptoms without blocking testosterone’s anabolic effects (8). Higher dosages of test can also negatively impact cholesterol!, lowering HDL (9). Testosterone is probably the safest steroid around, but it cant be taken lightly, and Sustanon is no different.

The principal drawback to Sustanon is its cost. Compared with Omnadren, Testoviron, or even Sten (other testosterone products featuring various blends of Testosterone), the cost makes it prohibitive. An equal amount of one of the aforementioned products can be had for less than half the average cost of an amp of Sustanon. Sustanon, therefore, is no better or worse than any other form of testosterone…if the price is right.

References:
1. J Lab Clin Med. 1995 Mar;125(3):326-33.
2. Anat Histol Embryol. 2003 Apr; 32(2):70-9.
3. Health Psychol. 1990; 9(6):774-91.
4. Zhonghua Nan Ke Xue. 2003; 9(4):248-51
5. Curr Opin Clin Nutr Metab Care. 2004 May; 7(3):271-7.
6. J Appl Physiol. 2001 Mar; 90(3):850-6.
7. Can J Physiol Pharmacol. 1999 Apr; 77(4):300-4.
8. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E222-E227. Epub 2004 Sep 14.
9. J Clin Endocrinol Metab. 2004 Dec 21
10. 14. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1172-81.

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