MyMuscleWorld.com

muscle building blog, workout tips, anabolic steroids use, nutrition and more

www.mymuscleworld.com header image 1

Testosterone Cypionate

(Testosterone base + cypionate ester)

Manufacturer: Asia Dispensary, British Dragon, Eco-Oils
Effective Dose (Men): 300-2000mg+ week
Effective Dose (Women): Not recommended
Active life: 15-16 days
Detection Time: 3 months
Anabolic/Androgenic ratio: 100/100

Testosterone is the hormone that makes men, well, men! Since it’s basically the most commonly used form of testosterone in America at this time, let’s take a look at testosterone cypionate, and examine the pros and cons of its ability to improve performance in athletics and bodybuilding,
Testosterone is the hormone responsible for many different physical and mental characteristics in males. It promotes sex drive, fat loss, helps with gaining and maintaining lean muscle mass and bone density, and may even protect against heart disease (1). All other steroids are actually the testosterone molecule altered soas to change the properties of the hormone. This would make testosterone the “father” of all other steroids employed by athletes today. In fact, testosterone is the standard for the anabolic/androgenic ratio we use—it’s a “perfect” 100 score, against which we measure all other steroids.

As I previously stated, testosterone is a highly anabolic and androgenic hormone, it has an anabolic (muscle building) rating of 100, making it a good drug to use if one is in pursuit of more size and strength. And if you aren’t in pursuit of more size and strength, then why would you be reading this, right? Well, let’s get on with it and look at exactly what makes testosterone a good mass builder. First, testosterone promotes nitrogen retention in the muscle (2). The more nitrogen the muscle holds the more protein the muscle stores. Testosterone can also increase the levels of another anabolic hormone, IGF-1, in muscle tissue (3). Testosterone also has the amazing ability to increase the activity of satellite cells (4). These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor to promote A.R dependant mechanisms for muscle gain and fat loss, (5) it also significantly increases the concentrations of the A. R in cells critical for muscle repair and growth and A.R in muscle (4)(6). Testosterone induces changes in shape and size, and also can change the appearance and the number of muscle fibers (7). Androgens like testosterone can protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones (8), thus inhibiting their action. In addition, Testosterone has the ability to increase red blood cell production (9), and a higher RBC count may improve endurance via better oxygenated blood. More RBCs can also improve recovery from strenuous physical activity. As you may have suspected, testosterone’s anabolic/androgenic effects are dose dependant; the higher the dose the higher the muscle building effect (10).

Athletes report massive strength gains while using testosterone (11). Testosterone improves muscle contraction by increasing the number of motor neutrons in muscle (4) and improves neuromuscular transmission (12). It also promotes glycogen synthesis (13) providing more fuel for intense workouts thus increasing endurance and strength. Also note that the water retention from testosterone use will cause the muscle to spring back when compressed during the lowering of a weight. Testosterone promotes aggressive and dominant behavior (14); this explains the boost of confidence that gives athletes the mental edge they need to move the heavy iron.
Testosterone is also good at promoting fat loss. Having an anti-estrogenic effect, it creates an ideal fat loss environment. Test binds to the A.R on fat cells resulting in fat break-down, and also prevents new fat formation (15). Another indirect action of fat loss that test produces is the nutrient portioning effect it has on muscle and fat. Since the body is building muscle at an accelerated rate, more of the food you eat is shuttled to muscle tissue and away from fat.
Is there anything testosterone can’t do?
Testosterone use does have some unwanted side effects that athletes should be aware of. Testosterone can convert to the female hormone estrogen (via aromatization) by the aromatize enzyme. Excessive estrogen can lead to some nasty side effects: breast tissue growth in men (gynecomastia), fat gain and reduced fat breakdown, loss of sex drive, testicular shrinkage and water retention. Water retention can increase blood pressure weakening blood vessels over a period of time. A class of drugs, called aromatize inhibitors, to stop the testosterone from converting to estrogencan easily stop the estrogenic side effects. The use of HCG during a testosterone cycle can prevent the testicular shrinkage. Testosterone can also interact with the 5 alpha-reductase enzyme. This action converts the testosterone to Dihydro-testosterone (DHT), a more androgenic form of the parent hormone. DHT has a high binding affinity to the tissues of the scalp resulting in hair loss in loss in users who suffer from male pattern baldness. DHT can affect the prostate as well, making it swell. This swelling can cause the gland to press against the bladder causing urinary problems. Drugs called 5alpha-reductase inhibitors can prevent these symptoms without blocking testosterone’s anabolic effects (16). Higher dosages of test can also negatively impact cholesterol, lowering HDL (17). Constantly ignoring this can lead to a series of serious health problems down the road.
Testosterone levels decrease as we age, with levels dramatically falling at 50-60 years of age (18). Low test levels lead to loss of muscle mass and strength, gains in fat, and loss of sex drive (18). So, it is a good idea to replace testosterone with an outside source. Supplementing testosterone in older adults with sub-optimal levels may prevent or delay Alzheimer’s disease and other cognitive diseases, protect nerves, and regenerate motor units; improve mood, memory, appetite, sex drive, and bone mass; and may decrease the risk of heart attack and stroke (19)(20)(21) (22). This shows that test replacement significantly improves the quality of life and may be a good option for middle-aged men. Caution should be taken when using higher dosages because of an increased risk of adverse side effects (23).
Testosterone cypionate is an injectable oil, which contains testosterone with the cypionate ester attached to the testosterone molecule. The ester denotes the release pattern of the test after it is injected into the body. This particular ester gives the testosterone an active life of 15-16 days, although blood levels of this drug fall sharply five days after post-administration, testosterone levels are still above baseline after a week (24). Stable blood levels can be achieved with injections once per week. Athletes often administer the drug twice weekly or every three to five days. On a funny note, many steroid users believe that test cyp is more, or less powerful, than the other popular injectable testosterone enanthate. The truth is that they are almost identical in release patterns, so there is virtually no difference between the two.
Testosterone is highly versatile and should be considered the “base” of anabolic/androgenic steroid cycles because of its muscle building potential as well as for the fact that it prevents the loss of sex drive that sometime affects those who neglect to use it with other HPTA suppressive anabolics, (especially the 19-nor family). Test can be used for any body-building goal whether it’s fat loss or muscle gain. An excellent drug for beginners, it’s also cheap, making it a top-notch choice for anyone interested in utilizing anabolics to reach their bodybuilding or athletic goals.

References:
1. Heart. 2004 Aug; 90(8):871-6.
2. J Clin Endocrinol Metab. 1997 Feb; 82(2):407-13.
3. Am J Physiol Endocrinol Metab. 2002 Mar; 282(3):E601-7.
4. Curr Opin Clin Nutr Metab Care. 2004 May; 7(3):271-7.
5. Curr Pharm Biotechnol. 2004 Oct; 5(5):459-70.
6. J Clin Endocrinol Metab. 2004 Oct; 89(10):5245-55.
7. Anat Histol Embryol. 2003 Apr; 32(2):70-9.
8. J Lab Clin Med. 1995 Mar; 125(3):326-33.
9. Zhonghua Nan Ke Xue. 2003; 9(4):248-51
10. J Clin Endocrinol Metab. 2003 Apr; 88(4):1478-85
11. online forums
12. J Appl Physiol. 2001 Mar; 90(3):850-6.
13. Can J Physiol Pharmacol. 1999 Apr; 77(4):300-4.
14. Health Psychol. 1990; 9(6):774-91.
15. Biochim Biophys Acta. 1995 May 11; 1244(1):117-20.
16. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E222-E227. Epub 2004 Sep 14.
17. J Clin Endocrinol Metab. 2004 Dec 21
18. Sports Med. 2004; 34(12):809-24.
19. Heart. 2004 Aug; 90(8):871-6.
20. Pol J Pharmacol. 2004 Sep-Oct; 56(5):509-18.
21. Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3):1140-5. Epub 2002 Jan 22.
22. J Gerontol A Biol Sci Med Sci. 2001 May; 56(5):M266-72.
23. J Clin Endocrinol Metab. 2005 Feb; 90(2):678-88. Epub 2004 Nov 23.
24. Fertility and Sterility 33. (1980) 201-3

TopOfBlogs