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Why Trenbolone is effective at fat loss

July 28th, 2009 · No Comments

trenabolic-trenbolone

Trenbolone is effective at fat loss

While reading this article keep in mind that Tren (trenbolone finaplix) binds to the androgen receptor incredibly well.

The Androgen Receptor
There are many mechanisms behind the ability of androgens to reduce body fat. However, one key determinant of the amount of adipose tissue reduced is that particular androgen’s ability to bind to the AR.

I need to mention that most androgens interact with both AR and GR (Glucocorticoid Receptors). We’ll touch on that later. For now, let me explain why it matters how well an androgen binds to the AR in terms of reducing adipose tissue. Most of you know that ARs are present in tissue such as muscle. This is one of the mechanisms behind their ability to induce muscular hypertrophy. Now what does this have to do with body fat? Simple, AR’s are present in adipose tissue as well. (1)

What does this mean? Well, it’s been shown that the higher the density of ARs, the more that lipid uptake is inhibited. (2) It’s also been shown that androgens that bind avidly to the AR cause an increase or upregulation of AR in adipocytes. (1) I think the greater the androgen binds to the AR, the more upregulation of AR in adipocytes occurs. This would lead to a significant reduction in subcutaneous adipose tissue. (3)

Notice that I specifically mentioned subcutaneous adipose tissue (fat right beneath the skin) and not visceral adipose tissue (fat around the internal organs). Why did I bother to differentiate between the two? Simple. For the most part, we bodybuilders are concerned only with subcutaneous adipose tissue. Visceral fat doesn’t have much of an effect on a person’s appearance. For that reason, we’re only concerning ourselves with subcutaneous adipose tissue.

Now, what other mechanisms of action can account for the effects seen with those steroids that bind tightly to the AR? Well, those that bind tightly to the AR will decrease LPL (Lipoprotein Lipase), which is an enzyme that causes lipid accumulation. (4) They may also decrease Acetyl-CoA Carboxylase and Fatty Acid Synthetase.(5)

Another interesting note is that androgens have been shown to increase adenyl cylclase as well. This is the enzyme which is responsible for the conversion of cytoplasmic ATP into cyclic AMP. Increasing its concentrations is a good thing, in other words.

Sources:
1. Dieudonne MN, et al. “Androgen receptors in human preadipocytes and adipocytes: regional specifities and regulation by sex steroids.” Am J Physiol 1998 Jun;274(6 Pt 1): C1645-52

2. Sjogren J, et al. “Androgen binding hormone to adipose tissue in rats.” Biochim Biophys Acta 1995 May 11;1244(1):117-20

3. De Pergola G, et al. “Up-regulation of androgen receptor binding in male rat fat pad adipose precursor cells exposed to testosterone: study in a whole cell assay system.” J Steroid Biochem Mol Biol 1990 Nov 30;37(4):553-8

4. Xu X, et al. “The effects of androgens on the regulation of lipolysis in adipose precursor cells.” Endocrinology 1990 Feb;126(2):1229-34

5. Burch L, et al. “Effect of anabolic steroids on lipogenic and lipolytic enzymes in sheep tissues.” Horm Metab Res 1982 Jan;14(1):52-3

Tags: Anabolic Steroids · Steroids Cycles

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